100+ responses on a post asking just this question cover a wide range of advice, with several recurring themes emerging.
One of the clearest themes: it’s much more dangerous!
Also, is the DM obligated to balance encounters, gold pieces as XP, hirelings, THAC0, skip the backstory until 3rd level, squad tactics and party balance, and a lot more! What would YOU say?
Don’t get lost.
Never split the party.
Protect the cleric.
Listen to the members of your party who HAVE played OSD&D before.
If the sexism in OD&D bothers you, consider that it was Gary trying to be “realistic” about the roles of women in the middle ages: “they are smaller and weaker and just there to have and raise babies…”. So you can all agree that an “ordinary” medieval woman would not be arming herself and becoming part of a dungeon adventuring party: so the female characters in your party should NOT be saddled with the special disadvantages that OD&D calls for. Unless the scenario calls for a helpless probable victim that you are supposed to be protecting or a female magic user who might have low strength etc, but think she can depend on her spells to survive.